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In answering the latter part of the question, "Can A Christian Lose Their Salvation". The Bible says no. One who is saved "has everlasting life, and . . . is passed from death unto life" (John 5:24). Eternal life by definition cannot be temporary. It is the present possession of all those who have truly trusted Christ. Romans 8:28-39 reveals clearly that there is nothing in the universe that can separate the elect from the love of God. The One who chose to save you "is able to keep you from stumbling, and to make you stand in the presence of His glory blameless with great joy" (Jude 24).

It is an important distinction that according to Scripture, people who profess to know Christ at one time but later deny Him were never really saved to begin with. 1 John 2:19 says, "They went out from us, but they were not really of us; for if they had been of us, they would have remained with us; but they went out, in order that it might be shown that they all are not of us."

A true believer will never depart from the faith (Philippians 1:6), so those who do so are revealing that they were never truly saved (John 8:31; Hebrews 3:14).

Of course it always needs to be stated that even true Christians sin (1 John 1), however, and because of that may lack assurance of salvation (Psalm 51:12). A failure to grow spiritually can also rob us of the confidence that we are God's children (2 Peter 1:9). But anyone indwelt by the Holy Spirit is secure eternally, because He is the "deposit guaranteeing our inheritance" (Ephesians 1:14).

I wish I could say it was! But few things are further from the truth. One of the hardest things for anyone to believe is the concept of an eternal hell, and that once a person dies that's it - but there is no other thing taught in Scripture than that. In Hebrews 9:27, "And as it is appointed unto men once to die, and after this the judgment". There isn't anything in between. Death will end the possibility of salvation for everyone. That's why evangelism is so crucially important.

Listen to John 8:21, "Then said Jesus again unto them..." Jesus is having a little dialogue with the Pharisees. Jesus said to them, "I go my way, and you shall seek me," now watch, "...and shall die in your sins..." And what is the result? "...where I go," What? "...you can't come." Once you die in your sins the door is closed - "'Where I go you cannot come.' Then the Jews said, 'Will he kill himself? Because he says, Where I go, you can't come?'" [John 8:22]. That's a horrible answer. Just a quick FYI, the Jews felt that the deepest pit; the blackest death; belong to people who killed themselves. Why? Because they saw man created in the image of God, and to take your own life was a crime, and so they believed that the deepest pit was for those who killed themselves. So, when Jesus said, "You are going to die, in your sins, and where I go you can't come,"- in mockery they said, "What, you're gonna kill yourself? Are you going to go to that lowest level of the pit where we won't ever go?" And Jesus really got strong in verse 23, He said, "You are from the pit; you are from beneath; I am from above: you are of this world; I am not of this world. I said therefore unto you, you shall die in your sins: for if you believe not that I am he, you shall die in your sins. And where you won't go is above, where I am from." Do you see the point? There is no second chance - a person only has this lifetime. Then comes judgment.

For every Christian there is a struggle at one time or another with depression. In the midst of this there is ultimately the struggle of hope. Let it be said at the very beginning, that there is nothing wrong with the object of our hope - Jesus Christ. He is not defective in any way whatsoever. But the view from the struggling Christian can often times be obscured with a myriad of obstacles be it disease, pain, the pressures of life, or by any other fiery dart hurdled against them.

There is only one way to fight this giant and every single one of us needs to fight it in the same way, by getting our view of Christ and His promises into focus. Let it be said that all discouragement and depression is directly related to the “blockage” of our view of hope, and we desperately need to clear the obstacle and fight like crazy to see clearly how precious Christ is.

This implies we have work to do! So often we go through life expecting good and happy things when we live in a world given over to the lap of Satan. We tend to forget that in order to have a garden I have to weed a whole lot more than I harvest.

There is another kind of work that needs to get done, a work for each other. There seems to be the tradeoff that when one person is struggling, another person is thriving. The point of that is so that the body would work together and the strong would minister to the weak (Gal. 6). Then the roles might be reversed the very next week or month, and the one who was just weak becomes strong to help the other who has now become weak.

Can a Christian be depressed? You bet they can, I seriously wonder about the Christian who says they never are! The more important question is what do we do when we do feel depressed. As we come up out of a discouragement we need to be ministering to others.
This is exactly what Paul said in 2 Corinthians 1:4 where he speaks about comforting others with the comfort with which he had been comforted by God. Listen, God ordains that one person walk through a valley, find comfort in the valley (by focusing on Christ and His promises), come out of that valley, turn around, go back to the beginning of that same valley, and then vigilantly watch for and help other people walk through that same valley administering the healing balm of comforts they discovered there. Can I add this, if you don’t get your eyes off yourself and on to others it will only be a matter of time before you sink into further depression.